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Updated: Jun 22, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
10:51

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

Allosteric effects govern nuclear receptor action: DNA appears as a player

Hinrich Gronemeyer1, William Bourguet

  • 1Department of Cancer Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), BP 10142, 67404 Illkirch Cedex, CU de Strasbourg, France. hg@igbmc.fr

Science Signaling
|June 4, 2009
PubMed
Summary

DNA can allosterically modulate glucocorticoid receptor activity, revealing a novel regulatory mechanism for nuclear receptors (NRs). This discovery offers new insights into how NRs fine-tune gene networks involved in various physiological processes.

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