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Focus on the ONTARGET results

Henry L Elliott1

  • 1Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK. henrylelliott@aol.com

Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
|June 4, 2009
PubMed

Insights

Telmisartan and ramipril demonstrated equivalent cardiovascular protection in high-risk patients. Telmisartan showed better tolerability, with fewer discontinuations, making it a strong option for renin-angiotensin system blockade.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Renin-angiotensin system (RAS) blockade is crucial for managing patients with high cardiovascular risk.
  • Ramipril is a widely accepted 'reference' drug for RAS blockade.

Purpose of the Study:

  • To compare the cardiovascular protection of telmisartan versus ramipril in high-risk patients.
  • To evaluate the overall efficacy and tolerability of telmisartan compared to ramipril.

Main Methods:

  • The ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial (ONTARGET) involved 23,400 high-risk cardiovascular patients.
  • Direct comparison of telmisartan and ramipril effectiveness and tolerability.

Main Results:

  • Telmisartan and ramipril were found to be therapeutically equivalent in providing cardiovascular protection.
  • Telmisartan exhibited a superior overall efficacy/tolerability ratio due to fewer patient discontinuations.

Conclusions:

  • Telmisartan is the only angiotensin II blocker with demonstrated cardiovascular protection equivalent to ramipril.
  • Telmisartan offers a favorable efficacy and tolerability profile for RAS blockade in high-risk individuals.

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