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Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
Published on: May 30, 2011
Arterial spin-labeled perfusion MRI in basic and clinical neuroscience
John A Detre1, Jiongjiong Wang, Ze Wang
1Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA. detre@mail.med.upenn.edu
Current Opinion in Neurology
|June 4, 2009
Summary
Arterial spin labeling (ASL) MRI offers a noninvasive method to measure cerebral blood flow (CBF), serving as a valuable biomarker for brain function in neuroscience research and clinical applications.
Area of Science:
- Neuroscience
- Medical Imaging
- Physiology
Background:
- Arterial spin labeling (ASL) is a noninvasive magnetic resonance imaging (MRI) technique.
- ASL quantifies regional cerebral blood flow (CBF) using an endogenous tracer.
- CBF is closely linked to neural metabolism, indicating broad applications in brain function studies.
Purpose of the Study:
- To review ASL methodologies and clinical applications.
- To highlight the utility of ASL perfusion MRI in neuroscience research.
- To demonstrate ASL's role as a biomarker for brain function.
Main Methods:
- Review of ASL techniques and their advancements.
- Analysis of ASL's application in human neuroscience research.
- Examination of ASL in studying resting brain function and responses to stimuli.
Main Results:
- ASL technology has significantly improved.
- ASL perfusion MRI is a valuable diagnostic and research tool.
- ASL can elucidate resting brain function patterns and state effects.
Conclusions:
- ASL perfusion MRI is a versatile biomarker for regional brain function.
- ASL can be integrated into multimodal MRI examinations.
- ASL's quantification of physiological parameters supports multisite and longitudinal studies.
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