[Experimental-morphological study of hybrid implantation material integration into bone tissue]
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Updated: Jun 22, 2026

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells
Published on: July 14, 2023
Abstract:
The authors developed new material based upon polytetrafluoroethylene (Teflon) with nanostructured metal and ceramic coatings. The task was formulated to study integrating potential of different chemical composition surfaces of intraosseous implants using Teflon with the mentioned above coatings as the experimental model. In experiments on rats using histomorphologic criterion there were compared implants from Teflon with Ti-, Ti-Ca-P-C-O-N- and Ti-Ca-Mn-K-C-O-N-coatings and Teflon without coating as the group for reference. It was shown that new experimental implant model based upon Teflon with different nanostructured coatings opened the possibility to profound investigation of interface contact substrate of metal (ceramic) surface with surrounding tissue structures. Optimal results upon the osteointegration criterion were received with Teflon + Ti-Ca-P-C-O-N-coating.

