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Related Experiment Video

Updated: Jun 22, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Localised peripheral primitive neuroectodermal tumour (PNET) of the conjunctiva.

Andrew S Moore1, Peter G Wilson, Penny McKelvie

  • 1Section of Paediatric Oncology, The Institute of Cancer Research & Royal Marsden Hospital, Sutton, Surrey, UK. andrew.moore@icr.ac.uk

Pediatric Blood & Cancer
|June 4, 2009
PubMed
Summary

A rare conjunctival tumor, peripheral primitive neuroectodermal tumor (PNET), was diagnosed in a teen. Treatment involved surgery and chemotherapy, with a positive outcome observed.

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Area of Science:

  • Ophthalmology
  • Oncology
  • Pathology

Background:

  • Conjunctival tumors are rare, and primitive neuroectodermal tumors (PNETs) are exceptionally uncommon in this location.
  • Early diagnosis and appropriate treatment are crucial for managing ocular tumors.

Observation:

  • A 16-year-old male presented with a 3-month history of an asymptomatic, enlarging conjunctival lesion.
  • Histologic and immunohistochemical examination of an excisional biopsy revealed features of a peripheral PNET adjacent to a benign compound nevus.

Findings:

  • Fluorescence in situ hybridization (FISH) analysis confirmed the diagnosis by demonstrating a split-signal at 22q12.
  • Staging investigations were negative, indicating a primary conjunctival lesion.
  • The patient underwent local wide re-excision and chemotherapy.

Implications:

  • This case highlights the importance of considering rare tumors like PNET in the differential diagnosis of conjunctival lesions.
  • Successful management with a combination of surgery and chemotherapy offers a potential treatment paradigm for similar cases.
  • Long-term follow-up is essential to ensure sustained remission and monitor for any recurrence.