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Elena Aznar1, Carmen Coll, M Dolores Marcos

  • 1CIBER de Bioingeniería, Biomaterials y Nanomedicina, Instituto de Reconocimiento Molecular y Desarrollo Tecnológico, Centro mixto Universidad Politécnica de Valencia, Spain.

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Researchers developed a smart mesoporous silica material that uses borate as a molecular tap to control dye release. This borate-triggered system acts as a pH-responsive gate, enabling controlled delivery of encapsulated molecules.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Supramolecular Chemistry

Background:

  • Development of stimuli-responsive materials for controlled release applications.
  • MCM-41 mesoporous silica as a versatile scaffold for molecular encapsulation.
  • Functionalization of nanomaterials with saccharides for specific molecular interactions.

Purpose of the Study:

  • To engineer a hybrid mesoporous silica system for controlled guest molecule release.
  • To investigate the role of borate ions as molecular triggers for release inhibition.
  • To explore the pH-responsive behavior of the functionalized material.

Main Methods:

  • Synthesis of MCM-41 mesoporous silica functionalized with saccharides.
  • Encapsulation of the dye [Ru(bipy)(3)](2+).
  • Experimental studies on dye release inhibition by borate ions.
  • Molecular dynamic simulations to elucidate the mechanism of borate-driven pore closure.

Main Results:

  • Demonstration of borate-selective inhibition of dye mass transport from mesoporous silica.
  • Identification of borate-saccharide interaction leading to boroester formation and pore constriction.
  • Observation of pH-controlled release: closed at neutral pH, open at acidic pH due to hydrolysis.
  • Molecular simulations confirming borate-induced pore size reduction and restricted saccharide mobility.

Conclusions:

  • The developed MCM-41 based system functions as a borate-gated, pH-responsive nanocontainer.
  • Borate ions act as selective molecular triggers, controlling the release of encapsulated dyes.
  • The system offers a novel platform for designing smart drug delivery or sensing applications.