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Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
Published on: May 17, 2019
Gene expression-based prognostic and predictive markers for breast cancer: a primer for practicing pathologists
Chungyeul Kim1, Yusuke Taniyama, Soonmyung Paik
1Division of Pathology, National Surgical Adjuvant Breast and Bowel Project Foundation, Pittsburgh, Pennsylvania, USA.
Archives of Pathology & Laboratory Medicine
|June 5, 2009
Summary
Gene expression assays for breast cancer are clinically useful but still evolving. Future tests require more clinical specificity for optimal patient management.
Area of Science:
- Oncology
- Molecular Diagnostics
- Genomics
Background:
- Commercial gene expression-based prognostic assays for breast cancer are available.
- These tests are covered by insurance for patient care.
Purpose of the Study:
- To inform pathologists about gene expression assays for breast cancer.
- To detail assay types, differences, and clinical oncologist use in patient management.
Main Methods:
- Literature review and analysis of unpublished data.
- Focus on conceptual understanding of assay technology and variations.
Main Results:
- Gene expression assays offer clinical utility in breast cancer management.
- Current assays are undergoing continuous development and refinement.
Conclusions:
- Gene expression assays are valuable tools for breast cancer prognosis.
- Future assay development must prioritize clinical context specificity for enhanced utility.
