Related Experiment Video
Updated: Jun 22, 2026
In Vivo Imaging of Cx3cr1gfp/gfp Reporter Mice with Spectral-domain Optical Coherence Tomography and Scanning Laser Ophthalmoscopy
Published on: November 11, 2017
Comparison of retinal thickness measurements between three-dimensional and radial scans on spectral-domain optical
Kaori Sayanagi1, Sumit Sharma, Peter K Kaiser
1Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Purpose:
To compare retinal thickness (RT) measurements between traditional 6 radial line scans and three-dimensional (3D) scans using spectral-domain optical coherence tomography (SD-OCT).
Design:
Prospective, consecutive case series.
Methods:
Twenty eyes of 17 patients with macular diseases and 8 healthy subjects were scanned using 2 different methods (3D scan and 6 radial line scan) using 2 different SD-OCT devices (Topcon OCT-1000 [Topcon Inc, Paramus, New Jersey, USA] and Canon SPOCT [(Canon/Optopol Inc, Depew, New York, USA]) by an experienced OCT operator. In 16 eyes, the data of TD-OCT were also obtained for comparison. The RT in 9 regions based on Early Treatment Diabetic Retinopathy Study areas were analyzed and compared. Bland-Altman plots were used to evaluate agreement.
Results:
In the eyes with macular diseases, there was no significant difference in the RT between 3D and 6 radial line scans except the center subfield (P = .011) on the Topcon OCT-1000, and inner inferior (P = .031) and outer nasal (P = .014) areas on the Canon SPOCT. In the healthy subjects, there was no significant difference between the different scans on both SD-OCT devices. The 95% limit of subjects was 3.2 to 30.6 microm and 16.7 to 28.3 microm in the eye with macular diseases on OCT-1000 and SPOCT, respectively, and 6.7 to 13.6 microm and 10.8 to 32.3 microm in healthy subjects on OCT-1000 and SPOCT, respectively.
Conclusions:
Preliminary results suggest the RT obtained by the 2 different scan patterns, 3D scan and 6 radial line scan, did not differ significantly on SD-OCT.
