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Related Experiment Video

Updated: Jun 22, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

Structure-function relationship depends on glaucoma severity.

M Gonzalez-Hernandez¹, L E Pablo, K Armas-Dominguez

¹Department of Ophthalmology, University Hospital of the Canary Islands, University of La Laguna, La Laguna, Spain.

The British Journal of Ophthalmology

|June 5, 2009

Summary

This summary is machine-generated.

The relationship between visual field sensitivity and retinal nerve fiber layer thickness in glaucoma does not differ significantly between linear and logarithmic models across disease stages. This suggests variability in normal morphology and test limitations may explain observed patterns in glaucoma patients.

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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

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Published on: May 25, 2020

Area of Science:

Ophthalmology
Neuroscience
Biomedical Engineering

Background:

Glaucoma is a progressive optic neuropathy characterized by structural damage and functional vision loss.
Understanding the structure-function relationship is crucial for diagnosing and managing glaucoma at various stages.

Purpose of the Study:

To investigate the relationship between standard automated perimetry mean sensitivity (SAP-MS) and retinal nerve fiber layer (RNFL) thickness in different stages of glaucoma.
To determine if linear or logarithmic models best describe this relationship.

Main Methods:

Analyzed data from 228 controls and 1007 glaucoma patients (suspected, early, moderate, advanced).
Calculated Pearson coefficient of variation (PCV) for SAP-MS and RNFL thickness.
Employed piecewise linear regression to identify a breakpoint and compare linear and logarithmic relationships between SAP-MS and RNFL thickness.

Main Results:

The PCV for SAP-MS was 6.19% and for RNFL was 29.27%.
No significant difference was found between logarithmic and linear relationships for SAP-MS and RNFL thickness, both above (p=0.950) and below (p=0.884) the identified breakpoint (SAP-MS = 22.42 dB).

Conclusions:

The structure-function relationship in glaucoma does not significantly differ between linear and logarithmic models, even when stratified by disease severity.
Observed relationships may be influenced by high variability in normal RNFL morphology and limitations in the dynamic range of imaging tests for moderate to severe glaucoma.