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Updated: Jun 22, 2026

Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice
Published on: September 13, 2024
Distinct gender-related sleep pattern in an acute model of TMJ pain
T C B Schütz1, M L Andersen, A Silva
1Department of Psychobiology, Universidade Federal de São Paulo, Escola Paulista de Medicina, Rua Napoleão de Barros, 925, Vila Clementino, SP-04024-002, São Paulo, SP, Brazil. tschutz@psicobio.epm.br
Abstract:
Since it is recognized that acute inflammation of the temporomandibular joint results in sleep disturbances in male rats, and that the orofacial region may display a site-specific effect of ovarian hormones on nociception, we hypothesized that distinct genders would respond differently when subjected to this inflammatory acute orofacial pain. Sleep was monitored after injection of saline/Freund's adjuvant into the temporomandibular joint in male and female (proestrus and diestrus phases) rats. Progesterone and stress-related hormones were also assessed. In males, Freund's adjuvant induced a significant nociceptive response and sleep disturbances. Behavior and sleep architecture in the females remained unaffected. Our results suggest that females and males present distinct responses to an acute model of orofacial pain.
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