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Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

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Hypoglycemia and Glucagon

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Related Experiment Video

Updated: Jun 22, 2026

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
07:13

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

A practical approach to hypocalcaemia in children.

Nick Shaw1

  • 1Department of Endocrinology, Birmingham Children's Hospital, Steelhouse Lane, Birmingham, UK. nick.shaw@bch.nhs.uk

Endocrine Development
|June 5, 2009
PubMed
Summary

Hypocalcaemia, a common mineral metabolism disorder in children, stems from issues with parathyroid hormone, vitamin D, or calcium-sensing receptors. This study outlines a practical approach for diagnosing and managing these conditions.

Area of Science:

  • Pediatric endocrinology
  • Mineral and bone disorders
  • Calcium homeostasis

Background:

  • Hypocalcaemia is a frequent clinical problem in pediatric populations.
  • It arises from diverse causes affecting mineral metabolism.
  • Key etiological categories include parathyroid hormone dysfunction, vitamin D metabolism abnormalities, and calcium-sensing receptor disorders.

Purpose of the Study:

  • To present a practical framework for investigating hypocalcaemia in children.
  • To guide the diagnosis of various hypocalcaemic disorders.
  • To outline subsequent management strategies for affected children.

Main Methods:

  • Systematic review of literature on pediatric hypocalcaemia.
  • Development of an etiological classification.

Related Experiment Videos

Last Updated: Jun 22, 2026

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
07:13

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

  • Clinical case-based approach to diagnostic algorithms.
  • Evidence-based recommendations for management.

    • Main Results:

    • Identified key investigations for differentiating causes of hypocalcaemia.
    • Provided diagnostic criteria for common and rare etiologies.
    • Outlined treatment principles based on underlying causes.
    • Emphasized the importance of timely and accurate diagnosis.

    Conclusions:

    • A structured approach facilitates the diagnosis and management of pediatric hypocalcaemia.
    • Understanding the specific etiology is crucial for effective treatment.
    • Early recognition and intervention improve patient outcomes.