[Comprehensive immunologic evaluation of patients with uveal and retinal pathology]

Clinical and immunologic examinations of 120 patients with central tapetoretinal abiotrophy, central serous choriopathy, central choroiditis, endogenic uveitis, thrombosis of the central retinal vein have revealed deviations in the T and B immunity systems and in autoimmune reactions to retinal S antigen, to uveopigmented antigens, and to human hepatic intracellular lipoprotein, as against the controls. The findings evidenced an imbalance of the T and B immunity parameters: reduced counts of T lymphocytes, theophylline-sensitive T suppressors, elevated immunoregulatory cell index, increased counts of B lymphocytes, circulating immune complexes, and blood serum immunoglobulins A and G. No essential shifts in leukocyte adhesion and antibody-dependent K cell cytotoxicity were found. The detected shifts are characteristic of the immune disorders common for various forms of uveoretinal abnormalities.