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[Uveitis, caused by Echo-11 virus]
Insights
ECHO-11 virus can cause severe uveitis in infants, leading to rapid iris damage and vision complications. Long-term follow-up revealed significant eye issues in most affected infants.
Area of Science:
- Ophthalmology
- Virology
- Pediatrics
Context:
- Enteroviral infections, particularly ECHO-11 virus, are a known cause of pediatric illness.
- Uveitis, inflammation of the middle layer of the eye, can have severe consequences in infants.
- Understanding the specific clinical course and complications of ECHO-11 virus-induced uveitis is crucial for timely intervention.
Purpose:
- To analyze the clinical manifestations and long-term outcomes of ECHO-11 virus-induced uveitis in infants.
- To describe the characteristic pathological changes in the iris and anterior chamber.
- To investigate the relationship between antibody titers and disease severity.
Summary:
- ECHO-11 virus-induced uveitis in 58 infants (2 weeks to 1.5 years) developed within 1-10 days of illness.
- Clinical signs included iris edema, hyperemia, pigment layer destruction, and rapidly progressing posterior synechiae, pupil deformation, and hypotonia.
- A 2-year follow-up showed significant visual impairments and complications in 60% of patients, including iridal fenestration and pupil deformities. Virus-neutralizing antibody production was noted, but no correlation with clinical course was found.
Impact:
- This study highlights the severe and potentially sight-threatening nature of ECHO-11 virus-induced uveitis in infants.
- It underscores the importance of early diagnosis and management to mitigate long-term ocular complications.
- Findings contribute to a better understanding of viral pathogenesis in pediatric ophthalmology.
Abstract:
Analysis of clinical manifestations of a total enteroviral infection with ECHO-11 virus-induced uveitis in 58 infants aged 2 weeks to 1.5 years has shown that uveitis develops on days 1-10 of the disease and is associated with a weak injection, endothelial edema, hyperemia and edema of the iris rapidly eventuating in destruction of the pigment lamina and fenestration. Posterior synechiae, pupil deformations, grave uveitis with hypotonia of 4-10 mm Hg are rapidly developing. A two-year follow-up has shown marked hemo- and hydrodynamic disorders, retarded growth of the involved eye, development of grave complications in 60 percent of patients. The most characteristic late complications were iridal fenestration, pseudocoloboma-type pupil deformation, formation of prelental films, often pigmented. The condition is associated with active production of virus-neutralizing antibodies in titers of 1:4 to 1:16384. No relationship between the clinical course and antibody titers was revealed.