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Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Diphtheria01:28

Diphtheria

Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
Inhibitors of Bacterial DNA Synthesis01:28

Inhibitors of Bacterial DNA Synthesis

Bacterial pathogens depend on precise and efficient DNA replication to sustain infection. Two type II topoisomerases—DNA gyrase and topoisomerase IV—are critical to this process, as they resolve DNA supercoiling and unlink chromosomes during replication. Fluoroquinolones, synthetic derivatives of quinolones, exploit this mechanism by stabilizing the transient DNA–enzyme cleavage complex, preventing strand religation, and causing lethal double-strand breaks. These antibiotics are selectively...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Hepatic Encephalopathy01:29

Hepatic Encephalopathy

DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...
Hepatic Drug Excretion: Enterohepatic Cycling01:17

Hepatic Drug Excretion: Enterohepatic Cycling

Enterohepatic cycling involves the active secretion of drugs and their metabolites into the bile via transporters in the canalicular membrane of hepatocytes. This secretion is an integral part of the digestive process, releasing these substances into the gastrointestinal (GI) tract.
Post-release drugs and metabolites can be reabsorbed into the body from the intestine. For conjugated metabolites like glucuronides, reabsorption requires enzymatic hydrolysis by intestinal microflora. This...

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Related Experiment Video

Updated: Jun 22, 2026

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
11:36

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

Ceftriaxone-induced toxic hepatitis.

Erdal Peker1, Eren Cagan, Murat Dogan

  • 1Department of Pediatrics, Medical University of Yuzuncu Yil, 65100 Van, Turkey. pekererdal@hotmail.com

World Journal of Gastroenterology
|June 5, 2009
PubMed
Summary

Ceftriaxone, a common antibiotic, can cause drug-induced liver injury (DILI). This case highlights toxic hepatitis in a patient treated with ceftriaxone for acute tonsillitis.

Area of Science:

  • Hepatology
  • Pharmacology
  • Infectious Diseases

Background:

  • Drug-induced liver injury (DILI) presents a wide clinical spectrum, from mild abnormalities to acute liver failure.
  • Ceftriaxone, a third-generation cephalosporin, is frequently used for pediatric infections due to its favorable pharmacokinetic profile and safety.
  • While rare, ceftriaxone-associated hepatitis has been previously documented.

Observation:

  • This report details a case of toxic hepatitis.
  • The patient received ceftriaxone for acute tonsillitis.

Findings:

  • The patient developed drug-induced toxic hepatitis.
  • This adverse event was associated with ceftriaxone treatment.

Implications:

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  • Clinicians should consider ceftriaxone as a potential cause of DILI, even in common infections.
  • Awareness of this association is crucial for prompt diagnosis and management of liver injury.
  • Further investigation into the mechanisms of ceftriaxone-induced hepatotoxicity may be warranted.