Related Experiment Video

Updated: Jun 22, 2026

Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model
10:32

Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model

Published on: April 2, 2021

A neuroectodermal hypothesis of the cause and relationship of myopia in retinopathy of prematurity

Sarita Beri1, Mridula Malhotra, Anuradha Dhawan

  • 1Lady Hardinge Medical College, D-38, Malka Ganj, New Delhi, India 110007.

Journal of Pediatric Ophthalmology and Strabismus
|June 6, 2009
PubMed

Insights

Increased lens thickness, not anterior segment length, is linked to myopia in preterm infants with retinopathy of prematurity (ROP). This may stem from altered neuroectodermal development in ROP.

Area of Science:

  • Ophthalmology
  • Neonatology
  • Developmental Biology

Background:

  • Retinopathy of prematurity (ROP) is a significant cause of visual impairment in preterm infants.
  • Myopia is a common complication of ROP, but its underlying mechanisms are not fully understood.
  • Oculometric parameters and their relationship with ROP and myopia require further investigation.

Purpose of the Study:

  • To analyze oculometric parameters in preterm infants with and without ROP.
  • To determine the effect of ROP on myopia development.
  • To investigate the specific ocular changes associated with myopia in ROP.

Main Methods:

  • Prospective study involving preterm infants screened for ROP.
  • Comprehensive eye examinations including fundus examination, cycloplegic refraction, and biometric measurements.
  • Data collected across three follow-up visits.

Main Results:

  • Forty-two preterm infants were analyzed, divided into ROP and non-ROP groups.
  • Preterm infants with ROP and myopia exhibited increased lens thickness compared to controls.
  • Anterior segment length remained similar across groups, suggesting it's not a primary factor in ROP-associated myopia.

Conclusions:

  • Increased lens thickness, independent of anterior segment length, is a key factor in myopia development in ROP.
  • This ocular change may be linked to aberrant neuroectodermal development in infants with ROP.
  • Understanding these mechanisms can inform strategies for managing visual development in preterm infants.
Abstract

More Related Videos

Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents09:28

Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents

Published on: September 16, 2020

Related Concept Videos

Anatomy of the Eyeball01:20

Anatomy of the Eyeball

The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle layer, the vascular tunic,...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...