[Effect of small doses of aspirin on thrombocyte aggregation]

Aspirin (acetylsalicylic acid--ASA) inhibits pletlets thromboxane (TXA2) synthesis as well as endothelial prostacycline (PGI2) synthesis. Aiming to prevent PGI2 synthesis attempts have been made to reduce ASA doses. Here are presented results of ASA effects in daily dose of 100 mg given to 26 patients with mean age of 54 years who suffered from myocardial infarction and were on rehabilitation. Except for ASA, none had consumed any anti-inflammatory drugs. Platelet aggregation was examined with ADP stimulation and spontaneous platelet aggregation in the circulation. The analyses were performed before ASA intake and 10 days after receiving 100 mg ASA each day. The results of the study have shown that both doses of ASA, 100 mg and 500 mg, have the same effects on pletelet aggregation measured by these methods.