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Related Concept Videos

Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Imaging Studies V: Intravenous Urography and Retrograde Pyelography01:22

Imaging Studies V: Intravenous Urography and Retrograde Pyelography

IntroductionIntravenous Urography (IVU) and Retrograde Pyelography (RP) are important diagnostic imaging techniques used to evaluate the urinary system. These methods help identify structural abnormalities, obstructions, and functional issues in the kidneys, ureters, and bladder. Both procedures use iodine-based contrast media to enhance the visibility of urinary tract structures on X-ray images, though they differ in their methods and indications.1. Intravenous Urography (IVU)Intravenous...

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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Urinary iodide concentration in hyperthyroid cats.

Jennifer Wakeling1, Jonathan Elliott, Aviva Petrie

  • 1Department of Veterinary Clinical Sciences, Royal Veterinary College, London, AL9 7TA, England.

American Journal of Veterinary Research
|June 6, 2009
PubMed
Summary
This summary is machine-generated.

Urinary iodide (UI) concentrations were lower in hyperthyroid cats and those with azotemia compared to euthyroid cats. This suggests a potential link between iodine levels and feline hyperthyroidism, warranting further investigation.

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Area of Science:

  • Veterinary Medicine
  • Endocrinology
  • Internal Medicine

Background:

  • Feline hyperthyroidism is a common endocrine disorder.
  • Urinary iodide (UI) concentration is a marker of recent iodine intake.
  • The relationship between UI and hyperthyroidism in cats is not fully understood.

Purpose of the Study:

  • To compare UI concentrations between euthyroid and untreated hyperthyroid cats.
  • To evaluate the impact of azotemia on UI levels in cats.
  • To assess changes in UI following treatment for hyperthyroidism.

Main Methods:

  • UI was measured in urine samples from 118 euthyroid and 88 hyperthyroid cats.
  • Statistical analysis (1-way ANOVA) was used to compare log-transformed UI (logUIs) between groups.
  • Renal function and estimated iodine intake were considered in the analysis.

Main Results:

  • Hyperthyroid cats had lower logUIs than euthyroid cats.
  • Azotemic cats exhibited lower logUIs compared to non-azotemic cats.
  • UI levels increased after hyperthyroid treatment, and no iodine deficiency was found in euthyroid cats.

Conclusions:

  • Lower UI concentrations are associated with untreated hyperthyroidism and azotemia in cats.
  • Further research is needed to explore the role of iodine intake in feline hyperthyroidism development.