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Updated: Jun 22, 2026
Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
Published on: September 28, 2022
The haptoglobin phenotype is associated with the Epstein-Barr virus antibody titer
Reinhart Speeckaert1, Marijn M Speeckaert, Elizaveta Padalko
1Department of Clinical Chemistry, Ghent University Hospital, Gent, Belgium.
Background:
Epstein-Barr virus (EBV) is a human herpes virus that persists for life and is associated with several neoplasms. Haptoglobin (Hp), a polymorphic multifunctional plasma protein, exerts several immunomodulatory effects. The present study investigated the influence of the genetic polymorphism of Hp on EBV serology.
Methods:
Patients without immunoglobulin G (IgG) titers of EBV were compared according to Hp phenotypes (Hp 1-1, Hp 2-1, Hp 2-2; determined by starch gel electrophoresis) in 208 individuals against 918 healthy subjects with unknown EBV status.
Results:
The Hp 1-1 phenotype was associated with a lower EBV antibody titer (p=0.0005).
Conclusions:
Our study confirms the involvement of the Hp phenotype in infection with EBV. Phenotypes with a higher Hp concentration (Hp 1-1 and Hp 2-1) are less prone to positive EBV serology.
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