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Applications of supercritical fluid chromatography-tandem mass spectrometry in pharmaceuticals
Maria Espinosa Bosch1, Antonin Jesús Ruiz Sánchez, Fuensanta Sánchez Rojas
1Department of Pharmacy, General Hospital, University Hospital Virgen del Rocío, Manuel Siurot S/n, 41013, Spain.
Abstract:
Supercritical fluid chromatography (SFC) is a fully mature technique and can readily be coupled to mass spectrometers relatively easily. In the last years, supercritical fluid chromatography coupled with mass spectrometry (SFC-MS) has had a great advance in productivity, due to increase in reliability and robustness of both SFC and MS systems, the need to push drug discovery faster, and as a potential solution to old problems unsolved and new problems yet to be encountered. This article will illustrate the role of SFC-MS analysis in drug discovery process.
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