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Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Published on: July 11, 2025

From malaria control to eradication: The WHO perspective.

Kamini Mendis¹, Aafje Rietveld, Marian Warsame

¹Global Malaria Programme, World Health Organization, Geneva, Switzerland.

Tropical Medicine & International Health : TM & IH

|June 6, 2009

Summary

Global malaria control efforts are reducing the disease burden, raising hopes for eradication. While malaria elimination is feasible in low-transmission areas with strong health systems, high-transmission regions require advanced tools and robust infrastructure for successful eradication.

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Area of Science:

Global health
Infectious disease epidemiology
Public health policy

Background:

Increased international funding and political commitment have accelerated malaria control efforts globally.
Reported malaria burden is decreasing worldwide, particularly in high-burden areas like tropical Africa.
Recent achievements have spurred discussions on the feasibility of global malaria eradication.

Observation:

A World Health Organization expert meeting assessed the feasibility of malaria eradication.
Lessons from the Global Malaria Eradication Programme (1950s-1960s) and current antimalarial tools inform the discussion.
Malaria control is feasible globally, significantly reducing morbidity and mortality.

Findings:

Malaria elimination is achievable in low-to-moderate transmission intensity areas with strong health systems.
Elimination necessitates a shift from population-based interventions to surveillance and response programs.
High and stable transmission areas, like tropical Africa, require more potent tools and stronger health systems for elimination.
Consolidating gains in high-burden countries is crucial before contemplating elimination strategies.
Drug and insecticide resistance pose significant threats to current malaria control and elimination strategies.

Implications:

Malaria eradication is a complex, long-term goal requiring sustained commitment and adaptive strategies.
Research and development of novel antimalarial tools are critical for overcoming resistance and achieving eradication.
Malaria control and elimination are complementary objectives in the global strategy against the disease.