Related Experiment Video
Updated: Jun 22, 2026
Extraction and Analysis of Taiwanese Green Propolis
Published on: January 7, 2019
Identification of a bioactive compound isolated from Brazilian propolis type 6
Myrella Lessio Castro1, Andréa Mendes do Nascimento, Masaharu Ikegaki
1Department of Physiological Sciences, Piracicaba Dental School, University of Campinas (UNICAMP), C.P. 52, 13414-903, Piracicaba, SP, Brazil.
Abstract:
A prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilian propolis type 6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC(50)=0.1756microM), strong antimicrobial activity (MIC range-0.73-6.6microg/mL; MBC range-2.92-106microg/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good.
