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In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
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Related Experiment Video

Updated: Jun 22, 2026

Optical Frequency Domain Imaging of Ex vivo Pulmonary Resection Specimens: Obtaining One to One Image to Histopathology Correlation
14:21

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Published on: January 22, 2013

Phase-resolved optical frequency domain imaging.

B Vakoc, S Yun, J de Boer

    Optics Express
    |June 6, 2009
    PubMed
    Summary
    This summary is machine-generated.

    Phase-resolved Doppler imaging using high-speed optical frequency domain imaging (OFDI) achieves excellent blood flow sensitivity. This technique accurately measures high flow rates without fringe washout, limited only by signal-to-noise ratio.

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    Area of Science:

    • Biomedical Optics
    • Medical Imaging
    • Fluid Dynamics

    Background:

    • Phase-resolved Doppler optical coherence tomography (OCT) is established for imaging blood flow.
    • Existing OCT techniques include time-domain and spectral-domain methods.
    • High-speed imaging is crucial for capturing dynamic flow phenomena.

    Purpose of the Study:

    • To present phase-resolved Doppler imaging using a high-speed optical frequency domain imaging (OFDI) system.
    • To demonstrate the system's capability in imaging blood flow dynamics.
    • To validate the accuracy and sensitivity of the developed technique.

    Main Methods:

    • Implementation of a high-speed OFDI system for phase-resolved Doppler imaging.
    • Correction of spurious timing-induced phase errors.
    • Acquisition of conventional and Doppler images in phantoms and human skin.

    Main Results:

    • Excellent flow sensitivity achieved, primarily limited by the signal-to-noise ratio.
    • Successful imaging of blood flow in an Intralipid phantom and human skin.
    • Demonstration of high flow rate measurement capability without fringe washout.

    Conclusions:

    • Phase-resolved Doppler OFDI offers high sensitivity for blood flow imaging.
    • The technique overcomes limitations of previous methods, such as fringe washout.
    • This advancement holds potential for enhanced biomedical imaging applications.