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Related Experiment Video

Updated: Jun 22, 2026

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
09:42

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

Published on: June 4, 2021

Laser-activated shape memory polymer intravascular thrombectomy device.

Ward Small Iv, Thomas Wilson, William Benett

    Optics Express
    |June 6, 2009
    PubMed
    Summary
    This summary is machine-generated.

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    A novel laser-activated device using shape memory polymer can mechanically remove brain blood clots, offering a new treatment for ischemic stroke. This technology aims to restore blood flow and prevent permanent disability.

    Area of Science:

    • Biomedical Engineering
    • Materials Science
    • Neurology

    Background:

    • Ischemic stroke is caused by brain blood clots (thrombi), leading to oxygen deprivation and potential permanent disability.
    • Current treatments like clot-dissolving drugs have limitations.
    • There is a need for alternative mechanical thrombectomy devices.

    Purpose of the Study:

    • To develop and evaluate an intravascular laser-activated therapeutic device for mechanical thrombus retrieval.
    • To investigate the optical and photothermal properties of the shape memory polymer (SMP) microactuator.
    • To demonstrate the clinical feasibility of this novel stroke treatment.

    Main Methods:

    • Characterization of SMP microactuator using thermal imaging.
    • Computer simulation of optical and photothermal behavior.

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    Published on: November 24, 2014

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    Last Updated: Jun 22, 2026

    A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
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    Published on: June 4, 2021

    Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model
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    Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model

    Published on: November 24, 2014

  • In vitro testing in a thrombotic vascular occlusion model.

    • Main Results:

    • The SMP device demonstrated effective mechanical retrieval of simulated thrombi.
    • Thermal imaging and simulations provided insights into device performance.
    • Successful deployment in an in vitro model validated the treatment concept.

    Conclusions:

    • The laser-activated SMP device shows promise as an alternative to current ischemic stroke treatments.
    • Mechanical thrombus retrieval using this technology can restore cerebral blood flow.
    • Further development could lead to a new clinical option for stroke patients.