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Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
Plasticity00:58

Plasticity

Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
The Synapse02:47

The Synapse

Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
Synaptic Signaling01:09

Synaptic Signaling

Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...

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Related Experiment Video

Updated: Jun 22, 2026

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
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Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

Heterosynaptic plasticity in the neocortex.

Marina Chistiakova1, Maxim Volgushev

  • 1Department of Neurophysiology, Ruhr-University Bochum, Bochum, Germany.

Experimental Brain Research
|June 6, 2009
PubMed
Summary
This summary is machine-generated.

Ongoing learning modifies neuronal synaptic weights through both homosynaptic and heterosynaptic plasticity. These complementary processes, influenced by synaptic predispositions, help maintain neural homeostasis and memory longevity.

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Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity
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Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
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Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity
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Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity

Published on: November 11, 2017

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Synaptic Plasticity

Background:

  • Neuronal learning continuously alters synaptic weights.
  • Synaptic plasticity can be homosynaptic (active synapses) or heterosynaptic (inactive synapses).

Purpose of the Study:

  • To propose that heterosynaptic plasticity complements homosynaptic plasticity.
  • To investigate the role of synaptic predispositions in plasticity.

Main Methods:

  • Theoretical argument and analysis of synaptic plasticity mechanisms.
  • Exploration of how predispositions influence synaptic weight changes.

Main Results:

  • Heterosynaptic plasticity may accompany homosynaptic plasticity during learning.
  • Synaptic predispositions dictate the direction and magnitude of plasticity.

Conclusions:

  • Heterosynaptic plasticity, guided by predispositions, aids in maintaining synaptic weight homeostasis.
  • This mechanism may extend memory trace lifetime in neuronal networks during continuous learning.