Related Experiment Video
Updated: Jun 22, 2026
Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
Published on: January 12, 2022
[Time domain OCT versus frequency domain OCT: measuring differences of macular thickness in healthy subjects]
S Chaber1, H Helbig, Ma Gamulescu
1Klinik und Poliklinik für Augenheilkunde, Universität Regensburg, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Deutschland. chaber@eye-regensburg.de
Background:
When changing from previously used time domain OCTs (TD-OCT) to frequency domain OCTs (FD-OCT) the question arises how to evaluate the progress of macular disease.
Methods:
OCT examinations and calculation (mapping) of the central retinal thickness were carried out in 40 healthy eyes with the Stratus OCT (Carl Zeiss Meditec Inc.; TD-OCT) as well as the Spectralis-OCT (Heidelberg Engineering GmbH 2008; FD-OCT).
Results:
The average central macular thickness was 218 microm in the Stratus OCT and 282 microm in the Spectralis-OCT. The average difference was 69 microm (p < 0.001). The mean value of single measurements showed a macular thickness of 195 microm when performed with the Stratus OCT and of 235 microm with the Spectralis-OCT. The difference of 40 microm was statistically significant (p < 0.001).
