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Related Experiment Video

Updated: Jun 22, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

Apolipoprotein E gene polymorphism in psoriasis.

Anthony Karpouzis¹, Rozina Caridha, Gregory Tripsianis

¹University Clinic of Dermatology, Democritus University of Thrace, Alexandroupolis 68100, Greece. karpouzis@bitservices.gr

Archives of Dermatological Research

|June 6, 2009

Summary

The apolipoprotein E gene

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Published on: August 21, 2016

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Last Updated: Jun 22, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

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Published on: April 4, 2018

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)

Published on: August 21, 2016

Area of Science:

Genetics
Immunology
Dermatology

Background:

Apolipoprotein E (ApoE) gene polymorphism is linked to various diseases.
ApoE influences T lymphocyte proliferation and infection resistance, suggesting a role in psoriasis.

Purpose of the Study:

To investigate the association between apolipoprotein E gene polymorphism and psoriasis vulgaris in Northern Greece.

Main Methods:

Case-control study involving 140 psoriasis vulgaris patients and 155 matched controls.
Genotyping performed using semi-nested polymerase chain reaction restriction fragment length polymorphisms (PCR-RFLPs).
Statistical analysis using conditional logistic regression.

Main Results:

The e2 allele of the ApoE gene was found at a significantly higher frequency in psoriasis vulgaris patients (6.1%) compared to controls (2.3%, P = 0.021).
This association was particularly pronounced in male patients (P = 0.031) and those with late-onset psoriasis vulgaris (P = 0.029).

Conclusions:

Apolipoprotein E gene polymorphism, specifically the e2 allele, is implicated in the pathogenesis of psoriasis vulgaris.
The e2 allele may represent a risk factor for developing late-onset psoriasis vulgaris.