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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...

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Related Experiment Video

Updated: Jun 22, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Stem cells and solid cancers.

Stuart A C McDonald1, Trevor A Graham, Stefanie Schier

  • 1Centre for Gastroenterology, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Blizard Building, 4 Newark Street, Whitechapel, London, E1 2AT, UK. stuart.mcdonald@cancer.org.uk

Virchows Archiv : an International Journal of Pathology
|June 6, 2009
PubMed
Summary
This summary is machine-generated.

Novel research reveals cancer stem cells may be more abundant than previously thought. Understanding their unique markers and development is key for potential cancer therapies.

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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

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Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
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Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors
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Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

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Area of Science:

  • Stem cell biology
  • Oncology
  • Cancer research

Background:

  • Significant advances in understanding stem cells within solid tumor tissues.
  • Identification of novel stem cell markers for multipotent cells.
  • Questioning the long-held belief of cancer stem cell scarcity.

Purpose of the Study:

  • Review the latest literature on stem cells and cancer stem cells in solid tumors.
  • Discuss the development of stem cells into cancer stem cells.
  • Explore unique markers for detecting cancer stem cells and their therapeutic potential.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of current research on stem cell markers and cancer stem cell biology.
  • Synthesis of findings regarding cancer stem cell abundance and detection.

Main Results:

  • Novel stem cell markers have been identified, confirming multipotency.
  • Evidence suggests cancer stem cells may not be as rare as previously believed.
  • Discussion on mechanisms of stem cell transformation into cancer stem cells.

Conclusions:

  • Recent advances provide new insights into stem cell biology within solid tumors.
  • The abundance and detection of cancer stem cells are areas of active investigation.
  • Understanding cancer stem cells offers potential avenues for novel cancer therapies.