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Related Experiment Video

Updated: Jun 22, 2026

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation

Published on: February 15, 2018

Dienogest and the breast.

Adolf E Schindler¹, Alexandria Henkel, Bernd Christensen

¹Institute for Medical Research and Education, Hufelandstrasse 55, D-45122 Essen, Germany. adolf.schindler@uni-due.de

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology

|June 6, 2009

Summary

High-dose dienogest treatment in women with endometriosis led to significant breast size reduction and regression of mastopathic changes. This progestogen therapy also showed a trend toward reduced duct diameter, indicating potential effects on breast tissue.

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Published on: January 8, 2015

Area of Science:

Gynecology
Endocrinology
Radiology

Background:

Endometriosis is a chronic inflammatory condition affecting women of reproductive age.
Dienogest is a progestogen commonly used for endometriosis treatment.
The effects of high-dose dienogest on breast tissue require further investigation.

Purpose of the Study:

To evaluate the impact of high-dose dienogest on breast tissue in women with endometriosis.
To assess changes in mammary gland size, mastopathic features, duct diameter, and fatty tissue composition.

Main Methods:

A pilot study involving 21 women with endometriosis.
Treatment with dienogest at 20 mg daily for 24 weeks.
Breast ultrasound examinations before and after treatment.

Main Results:

Significant reduction in mammary gland size (p < 0.023).
Regression of mastopathic changes observed in all participants.
Non-significant reduction in maximum duct diameter (p = 0.089).
Slight, non-significant increase in fatty tissue proportion (p = 0.348).

Conclusions:

High-dose dienogest therapy for endometriosis can lead to significant breast size reduction.
The treatment appears to induce regression of mastopathic changes in the breast.
Further research is warranted to fully understand the long-term effects on breast tissue.