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Published on: March 9, 2015
Hyperandrogenism in oligomenorrhoea with minimal or nil 'unwanted hair growth'
1Department of Obstetrics & Gynaecology, Vivekananda Institute of Medical Sciences, Kolkata, India. drsudhindra54@gmail.com
Aim:
To detect whether oligomenorrhoea with minimal or nil 'unwanted hair growth' is a hyperandrogenic problem.
Materials And Methods:
Fifty-nine women with oligomenorrhoea with modified Ferriman Gallway score (m FG) = <5 (Group A), 40 women with oligomenorrhoea with m FG score = > 6 (Group B) and 22 eumenorrhoeic non-hirsute 'control' women (Group C) were studied. Body mass index, Waist-hip ratio were noted during clinical examination. Serum testosterone, Sex hormone binding globulin, fasting insulin levels were measured in each woman. Free androgen index (FAI) was calculated.
Results:
No significant differences were noted in the clinical parameters. Though serum testosterone levels were within the normal ranges in Group A and Group B, they were significantly higher than that of Group C. Groups A and B had significantly higher FAI values and fasting insulin levels than Group C. Between Groups A and B there were no significant differences in any of the androgenic parameters studied.
Conclusion:
Oligomenorrhoea without definite hirsutism is an androgen excess disorder. Definition of biochemical hyperandrogenism needs more clarity. Hirsutism is not a sensitive indicator of hyperandrogenism. The role of insulin in this type of hyperandrogenism needs further studies.
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