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Extraction and Analysis of Taiwanese Green Propolis
Published on: January 7, 2019
Two new spirobiflavonoids from Abies chensiensis with moderate NO production inhibitory activity
Yong-Li Li1, Xian-Wen Yang, Su-Mei Li
1Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, P. R. China.
Abstract:
Phytochemical investigation of the aerial parts of Abies chensiensis afforded two new (compounds 2 and 3) and 27 known compounds, including the related compound larixinol ( 1). The structures of spirobiflavonoids 1- 3 were established using 1D and 2D NMR spectroscopic techniques. In addition, the structure of larixinol ( 1) was confirmed by X-ray crystallographic analysis. Compounds 1- 3 were evaluated for inhibitory activities against LPS-induced NO production in macrophages. Larixinol ( 1) showed moderate effects, with an IC(50) value of 60.0 microg/mL. In addition, it did not show any cytotoxicity on RAW 264.7 macrophages at 100 microg/mL.
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