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Local mobility in amorphous pharmaceuticals--characterization and implications on stability.

Sisir Bhattacharya¹, Raj Suryanarayanan

¹Department of Pharmaceutics, University of Minnesota, Minneapolis, Minnesota 55455, USA.

Journal of Pharmaceutical Sciences

|June 6, 2009

Summary

This summary is machine-generated.

Local molecular mobility, or beta-relaxations, significantly impacts amorphous pharmaceutical stability below the glass transition temperature (T(g)). Understanding these local motions is crucial for predicting drug stability.

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Area of Science:

Physical Pharmacy
Materials Science
Drug Stability

Background:

Amorphous pharmaceuticals' stability is linked to molecular mobility.
Global mobility (glass transition) is often studied, but doesn't fully explain instability.
Local mobility (beta-relaxations) below T(g) is increasingly recognized as critical.

Purpose of the Study:

To highlight the pharmaceutical significance of local motions (Johari-Goldstein relaxations) in amorphous systems.
To emphasize the impact of local mobility on amorphous phase stability.
To review the influence of additives like water on local motions.

Main Methods:

Review of existing literature on molecular mobility and amorphous pharmaceutical stability.
Discussion of the coupling model relating local and global mobility.
Overview of instrumental techniques for characterizing local motions.

Main Results:

Global mobility alone is insufficient to explain amorphous pharmaceutical instability.
Local mobility significantly influences physical and chemical stability.
Additives, such as water, can affect local motions in amorphous matrices.

Conclusions:

Local molecular motions are critical for amorphous pharmaceutical stability.
Characterizing local mobility, beyond global mobility, is essential for predicting drug behavior.
Further research into techniques for measuring local mobility is warranted.