Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Phenytoin hypersensitivity syndrome: a case report.

P A Howard1, P L Engen, M I Dunn

  • 1Department of Pharmacy, University of Kansas Medical Center, Kansas City 66103.

DICP : the Annals of Pharmacotherapy
|September 1, 1991
PubMed
Summary

A rare and potentially fatal phenytoin hypersensitivity syndrome occurred in a patient with heart condition. Early recognition and treatment with corticosteroids are crucial for managing this severe adverse drug reaction.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Warfarin for stroke prevention in octogenarians with atrial fibrillation.

The American journal of geriatric cardiology·2001
Same author

New recommendations from the 1999 American College of Cardiology/American Heart Association acute myocardial infarction guidelines.

The Annals of pharmacotherapy·2001
Same author

Aggressive diuresis for severe heart failure in the elderly.

Chest·2001
Same author

Optimizing beta-blocker use after myocardial infarction.

American family physician·2000
Same author

Guidelines for stroke prevention in patients with atrial fibrillation.

Drugs·2000
Same author

Guiding parents' use of the Internet for newborn education.

MCN. The American journal of maternal child nursing·1999

Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Toxicology

Background:

  • Phenytoin is an anticonvulsant medication.
  • Hypersensitivity syndrome is a rare but severe adverse drug reaction.
  • This syndrome is characterized by fever, rash, lymphadenopathy, eosinophilia, and hepatotoxicity.

Observation:

  • A 27-year-old male with corrected tetralogy of Fallot developed phenytoin hypersensitivity syndrome.
  • The patient was treated with phenytoin for exercise-induced sustained ventricular tachycardia.
  • The reaction manifested with typical signs including fever, rash, and elevated liver enzymes.

Findings:

  • Phenytoin therapy was discontinued upon diagnosis.
  • Intravenous methylprednisolone followed by oral prednisone was administered.

Related Experiment Videos

  • The patient showed clinical improvement within five days and was discharged on day 14.

    • Implications:

    • Phenytoin hypersensitivity syndrome can be life-threatening, with up to 40% mortality in cases with hepatotoxicity.
    • The reaction typically occurs within six weeks of initiating phenytoin.
    • Prompt diagnosis and corticosteroid treatment are essential for favorable outcomes and preventing fatal complications.