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Updated: Jun 22, 2026
Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
Published on: December 16, 2013
Tri-, tetra-, and hexanuclear copper(II) phosphonates containing N-donor chelating ligands: synthesis, structure,
Vadapalli Chandrasekhar1, Tapas Senapati, E Carolina Sañudo
1Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur-208016, India. vc@iitk.ac.in
Abstract:
Reaction of Cu(ClO(4))(2).6H(2)O with cyclopentyl phosphonic acid and 2,2'-bipyridine (bpy) in presence of triethylamine afforded a trinuclear compound [Cu(3)(C(5)H(9)PO(3))(2)(bpy)(3)(MeOH)(H(2)O)](ClO(4))(2) (2). The latter dimerizes to a hexanuclear derivative [Cu(6)(C(5)H(9)PO(3))(4)(bpy)(6)(MeOH)(4)](ClO(4))(4) (1) under prolonged reaction conditions. Reaction of CuCl(2) with cyclopentyl phosphonic acid and 2,2'-bipyridylamine (bpya) affords a tetranuclear derivative [Cu(4)(C(5)H(9)PO(3))(2)(mu-Cl)(2)(bpya)(4)](Cl)(2), (MeOH)(2) (3). Reaction of the latter with NaClO(4) also affords a trinuclear compound [Cu(3)(C(5)H(9)PO(3))(2)(mu-Cl)(bpya)(3)(H(2)O)](ClO(4)) (4). Double and single-bridged hexanuclear species, [{Cu(3)(C(5)H(9)PO(3))(2)(bpy)(3)(bpp)}(MeOH)(2)(H(2)O)(CH(2)Cl(2))(ClO(4))(2)](2) (5), [{Cu(3)(i-PrPO(3))(2)(bpy)(3)(4.4'-bpy)(H(2)O)}(H(2)O)(2)(ClO(4))(2)](2) (6), [{Cu(3)(C(5)H(9)PO(3))(2)(bpya)(3)(4.4'-bpy)(H(2)O)}(MeOH)(H(2)O)(ClO(4))(2)](2) (7), and [Cu(6)(t-BuPO(3))(4)(phen)(6)(4,4'-bpy)(MeOH)(4)](CH(2)Cl(2))(H(2)O)(ClO(4))(4) (8) (phen = 1,10-phenanthroline) were obtained by the reaction of an in situ generated trinuclear complex with appropriate bridging ligands 4,4'-bipyridine (4,4'-bpy) or 1,3-bis(4-pyridyl)propane (bpp). ESI-MS studies of these complexes reveal that 2-4 retain their structures in solution. Molecular structures of 2-8 were determined by X-ray crystallography. All the compounds reveal a capping coordination mode by tridentate phosphonate [RPO(3)](2-) ligands. Detailed magnetic studies on 2 and 4-8 reveal intramolecular antiferromagnetic interactions between Cu(II) S = 1/2 spins. 2 and 4 are excellent artificial nucleases and can convert supercoiled plasmid DNA (pBR322) into its nicked form without the aid of an external oxidant.
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