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Ligand binding and substrate discrimination by UDP-galactopyranose mutase

Todd D Gruber1, M Jack Borrok, William M Westler

  • 1Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706-1544, USA.

Journal of Molecular Biology
|June 9, 2009
PubMed
Summary

UDP-galactopyranose mutase (UGM) is essential for pathogenic microbes. We determined the first UGM-ligand complex structure, revealing insights into its catalytic mechanism and substrate selectivity for UDP-Galp and UDP-Galf.

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