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Updated: Jun 22, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
Clinical management of adrenocortical carcinoma
Martin Fassnacht1, Bruno Allolio
1Dept of Internal Medicine I, Endocrinology and Diabetes Unit, University Hospital, University of Würzburg, Würzburg, Germany. fassnacht_m@medizin.uni-wuerzburg.de
Abstract:
Adrenocortical carcinoma (ACC) is a rare and heterogeneous malignancy, and most of the diagnostic and therapeutic strategies are not fully established according to criteria of evidence-based medicine. However, recently collaborative efforts (e.g. International Consensus Conference 2003 and networks like the European Network for the Study of Adrenal Tumours (ENSAT)) have significantly advanced the field. This article summarizes current standards in the management of ACC. In patients with suspected ACC a thorough endocrine and imaging work-up is followed by complete (Ro) resection of the tumour by an expert surgeon and initiation of adjuvant mitotane. In advanced disease not amenable to radical resection, cytotoxic drugs will be added to mitotane. The most promising regimens (etoposide, doxorubicin, cisplatin plus mitotane and streptozotocin plus mitotane) are currently compared in an international phase-III trial. Several targeted therapies are under investigation (e.g. IGF-1 inhibitors, sunitinib, sorafenib) and may lead to new treatment options.
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