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Pharmacokinetic study of a carbamazepine nanoemulsion in beagle dogs
Gislaine Kuminek1, Jadel M Kratz, Rodrigo Ribeiro
1Programa de Pós-Graduação em Farmácia, Centro de Ciências da Saúde, Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, 88.040-900 Florianópolis, SC, Brazil.
Abstract:
This work describes the pharmacokinetics of a novel carbamazepine nanoemulsion. The plasma concentration profiles were determined in beagle dogs after i.v. bolus administration of a 5 mg/kg carbamazepine nanoemulsion and compared to the corresponding carbamazepine/hydroxypropyl-beta-cyclodextrin complex solution. Both formulations showed similar pharmacokinetic profiles and could represent valuable formulations in case of emergencies, when a rapid action in the central nervous system is desirable.
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