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Related Experiment Video

Updated: Jun 22, 2026

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
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Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

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Deep brain stimulation for pediatric movement disorders.

Warren A Marks1, John Honeycutt, Fernando Acosta

  • 1Department of Neurology, Cook Children's Medical Center, Fort Worth, TX, USA. Warren.Marks@cookchildrens.org

Seminars in Pediatric Neurology
|June 9, 2009
PubMed
Summary
This summary is machine-generated.

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Deep brain stimulation (DBS) offers a standard treatment for adults with tremor and dystonia. Pediatric DBS is emerging, requiring refined techniques to improve quality of life for young patients.

Area of Science:

  • Neurology
  • Neurosurgery
  • Pediatrics

Background:

  • Deep brain stimulation (DBS) has been a standard treatment for adult tremor and dystonia since 1997.
  • Over 50,000 adults have been treated, establishing DBS as a key therapy for pharmacoresistant conditions.
  • Dystonias encompass diverse disorders with genetic and extrinsic causes, treated with DBS in both children and adults.

Purpose of the Study:

  • To review the established role of Deep Brain Stimulation (DBS) in adult treatment.
  • To highlight the developing application and challenges of pediatric DBS.
  • To discuss the experience in establishing a dedicated pediatric DBS program.

Main Methods:

  • Review of existing literature and clinical experience with DBS for tremor and dystonia.

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Related Experiment Videos

Last Updated: Jun 22, 2026

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
09:46

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

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Published on: August 12, 2018

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  • Emphasis on the multidisciplinary team approach and awake surgery for precise lead placement.
  • Exploration of ongoing research into DBS for other neurological and psychiatric disorders.

    • Main Results:

    • DBS is a well-established, safe, and effective treatment for pharmacoresistant tremor and dystonia in adults.
    • Pediatric DBS is less common, with limited global centers possessing specialized experience.
    • Awake surgery, guided by a multidisciplinary team, ensures safe and accurate lead placement.

    Conclusions:

    • Deep brain stimulation (DBS) is a crucial therapy for adult movement disorders.
    • Pediatric DBS is an evolving field requiring further research and refined techniques.
    • Establishing dedicated pediatric programs is essential for optimizing outcomes and improving quality of life for young patients.