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Related Experiment Videos

Phlebosclerosis: disorder or disease?

H J Leu1, M Vogt, H Pfrunder

  • 1Institute of Pathology, University of Zürich, Switzerland.

VASA. Zeitschrift Fur Gefasskrankheiten
|January 1, 1991
PubMed
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Phlebosclerosis, a fibrotic venous wall degeneration, affects aged individuals and can occur early in life. While often benign in superficial leg veins, it may contribute to deep vein thrombosis and complicate varicose veins.

Area of Science:

  • Vascular Biology
  • Pathology
  • Gerontology

Background:

  • Phlebosclerosis is a fibrotic degeneration of the venous wall.
  • It is commonly observed in non-varicose veins of aged individuals.
  • Its incidence increases with age, but the degree of severity does not correlate with age.

Purpose of the Study:

  • To investigate the morphological characteristics of phlebosclerosis in superficial and deep leg veins.
  • To determine the clinical relevance and potential complications of phlebosclerosis.
  • To differentiate phlebosclerosis from arteriosclerosis.

Main Methods:

  • Morphological examinations of 318 subjects (168 men, 150 women).
  • Electron microscopy and immunohistological examinations in selected cases.

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  • Analysis of superficial leg veins (long saphenous vein, minor branches) and deep leg veins.

    • Main Results:

    • Phlebosclerosis affects both sexes and all superficial leg veins, predominantly the intima.
    • Marked phlebosclerosis can occur before age twenty.
    • In deep veins, intimal phlebosclerosis may lead to thrombosis; in varicose veins, it's a secondary complication impairing reflux.

    Conclusions:

    • Phlebosclerosis of superficial leg veins has minimal direct clinical impact but may affect contractility.
    • Phlebosclerosis in deep veins can be a precursor to thrombosis.
    • Phlebosclerosis is a late complication of, not a prerequisite for, varicose veins.