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Updated: Jun 22, 2026

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
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Brucellosis presenting as myelofibrosis: first case report.

Faris G Bakri1, Nazzal M Al-Bsoul, Ahmad Y Magableh

  • 1Department of Medicine, Division of Infectious Diseases, Jordan University Hospital, PO Box 13046, Amman 11942, Jordan. fbakri@yahoo.com

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|June 9, 2009
PubMed
Summary

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Brucellosis can cause myelofibrosis, a rare bone marrow disorder. This case report highlights successful treatment with doxycycline and rifampin, leading to complete recovery and resolution of myelofibrosis.

Area of Science:

  • Hematology
  • Infectious Diseases
  • Pathology

Background:

  • Brucellosis is a zoonotic infection with diverse clinical manifestations.
  • Pancytopenia and myelofibrosis are serious hematological conditions.
  • The association between brucellosis and myelofibrosis is not well-established.

Observation:

  • A 29-year-old woman presented with pancytopenia and myelofibrosis.
  • Brucella melitensis was identified as the causative agent.
  • The patient exhibited symptoms consistent with severe bone marrow involvement.

Findings:

  • The patient achieved complete recovery following treatment with doxycycline and rifampin.
  • Repeat bone marrow biopsy revealed hypercellularity, with resolution of myelofibrosis.

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  • This case represents the first documented instance of brucellosis-induced myelofibrosis.

    • Implications:

    • Brucellosis should be considered in the differential diagnosis of myelofibrosis, particularly in endemic regions.
    • Early diagnosis and appropriate antibiotic therapy are crucial for favorable outcomes.
    • Further research is warranted to understand the pathogenesis of brucellosis-related myelofibrosis.