Related Experiment Video

Updated: Jun 22, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Meningitis determined by oligosymptomatic dengue virus type 3 infection: report of a case

C N Soares1, M J Cabral-Castro, J M Peralta

  • 1Neurology Service, Hospital Universitário Antônio Pedro/Universidade Federal Fluminense, Rio de Janeiro, Brazil. cnsoares@predialnet.com.br

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|June 9, 2009
PubMed

Insights

Dengue virus infection can cause meningitis, a rare but serious complication. This mosquito-borne illness should be considered even without typical dengue symptoms.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Virology

Background:

  • Dengue virus is a significant global health threat, prevalent in over 100 countries.
  • Neurological complications of dengue infection are well-documented, including encephalitis and Guillain-Barré syndrome.
  • Meningitis is an infrequent manifestation of dengue virus infection.

Observation:

  • A case of a 24-year-old woman presenting with meningitis symptoms (fever, headache, nuchal rigidity) was observed.
  • The patient lacked typical dengue infection symptoms.
  • Cerebrospinal fluid analysis revealed lymphocytic pleocytosis with normal glucose and negative bacterial/fungal cultures.

Findings:

  • Dengue virus infection was confirmed via positive serum dengue PCR.
  • The patient's meningitis was directly attributed to dengue virus.

Implications:

  • This case underscores dengue virus as a potential cause of meningitis, particularly in endemic regions.
  • Meningitis can be the initial clinical presentation of dengue virus infection.
  • Dengue virus should be investigated in meningitis cases, even with atypical presentations.

More Related Videos

Protocol for Dengue Infections in Mosquitoes (A. aegypti) and Infection Phenotype Determination15:25

Protocol for Dengue Infections in Mosquitoes (A. aegypti) and Infection Phenotype Determination

Published on: July 4, 2007

Portable Paper-Based Immunoassay Combined with Smartphone Application for Colorimetric and Quantitative Detection of Dengue NS1 Antigen06:00

Portable Paper-Based Immunoassay Combined with Smartphone Application for Colorimetric and Quantitative Detection of Dengue NS1 Antigen

Published on: January 26, 2024

Related Concept Videos

Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Bacterial Meningitis01:24

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...