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Related Concept Videos

Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...

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Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
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Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

Mechanosensitive TRP channels in cardiovascular pathophysiology.

Ryuji Inoue1, Zhong Jian, Yasuhiro Kawarabayashi

  • 1Department of Physiology, Graduate School of Medical Sciences, Fukuoka University, Nanakuma 7-45-1, Jonan-ku, Fukuoka 814-0180, Japan. inouery@fukuoka-u.ac.jp

Pharmacology & Therapeutics
|June 9, 2009
PubMed
Summary

Mechanosensitive (MS)-TRP channels detect physical forces like stretch and shear, playing roles in cardiovascular function. Dysregulation of these channels is linked to cardiovascular diseases.

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Last Updated: Jun 22, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
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Exploring Arterial Smooth Muscle Kv7 Potassium Channel Function using Patch Clamp Electrophysiology and Pressure Myography

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Area of Science:

  • Physiology
  • Molecular Biology
  • Cardiovascular Research

Background:

  • Transient receptor potential (TRP) proteins are a superfamily of cation channels activated by diverse stimuli.
  • At least ten mammalian TRP channels are mechanosensitive, responding to mechanical forces.
  • These mechanosensitive (MS)-TRP channels exhibit complex and varied activation mechanisms.

Purpose of the Study:

  • To review mechanisms of mechanical activation and modulation of TRP channels.
  • To explore the role of MS-TRP channels in cardiovascular function.
  • To discuss the involvement of MS-TRP channels in cardiovascular pathophysiology.

Main Methods:

  • Literature review of existing studies on TRP channel mechanosensitivity.
  • Analysis of research on MS-TRP channel expression and function in the cardiovascular system.
  • Synthesis of evidence linking MS-TRP channels to cardiovascular disorders.

Main Results:

  • MS-TRP channels are activated by stimuli like membrane stretch and shear force.
  • Multiple mechanisms contribute to MS-TRP channel activation, including lipid bilayer mechanics and biochemical reactions.
  • MS-TRP channels are expressed in various cardiovascular tissues and influence cardiovascular functions.
  • Mechanical stress can synergize with neurohormonal pathways, impacting cardiovascular responses.

Conclusions:

  • MS-TRP channels are crucial regulators of cardiovascular physiology.
  • Aberrant function of MS-TRP channels is implicated in cardiovascular diseases such as hypertension and cardiac hypertrophy.
  • Further research into MS-TRP channels offers potential therapeutic targets for cardiovascular disorders.