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Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration
Published on: May 26, 2014
Ultrasound-mediated oxygen delivery from chitosan nanobubbles
Roberta Cavalli1, Agnese Bisazza, Alessandro Rolfo
1Dipartimento di Scienza e Tecnologia del Farmaco, Università di Torino, 10125 Torino, Italy. roberta.cavalli@unito.it
International Journal of Pharmaceutics
|June 9, 2009
Abstract:
Ultrasound (US) energy combined with gas-filled microbubbles has been used for several years in medical imaging. This study investigated the ability of oxygen-loaded chitosan bubbles to exchange oxygen in the presence or in the absence of US. Oxygen delivery is enhanced by sonication and both frequency and time duration of US affected the exchange kinetics.
