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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
Health issues of the late preterm infant
Ashwin Ramachandrappa1, Lucky Jain
1Department of Pediatrics, Division of Neonatology, Emory University School of Medicine, Atlanta, GA 30322, USA. ashwin_ramachandrappa@oz.ped.emory.edu
Insights
Late preterm infants, once considered low-risk, face higher mortality and increased complications. These infants require significant healthcare resources and may experience long-term neurodevelopmental issues.
Area of Science:
- Neonatology
- Perinatology
- Pediatric Medicine
Background:
- Late preterm infants (34-36 weeks gestation) were historically considered low-risk due to successful early treatments.
- Recent evidence indicates these infants are not as benign as previously assumed.
- They represent a significant proportion of preterm births and resource utilization.
Purpose of the Study:
- To highlight the increased risks and complications associated with late preterm birth.
- To underscore the need for renewed attention to this vulnerable population.
- To discuss potential long-term neurodevelopmental consequences.
Main Methods:
- Review of current evidence and emerging data on late preterm infants.
- Comparative analysis of outcomes between late preterm and term infants.
- Identification of common neonatal complications and resource utilization patterns.
Main Results:
- Late preterm infants exhibit increased mortality compared to term infants.
- Higher incidence of complications such as transient tachypnea of newborn (TTN), respiratory distress syndrome (RDS), and jaundice.
- Increased likelihood of prolonged neonatal intensive care unit (NICU) stays and feeding difficulties.
Conclusions:
- Late preterm infants represent a high-risk group requiring closer monitoring and management.
- These infants incur significant healthcare costs and resource demands.
- Potential long-term neurodevelopmental deficits warrant further investigation and follow-up.
Abstract:
"Late preterm" birth is not such an unusual occurrence; in fact these infants were the first group of premature infants who pediatricians learned to treat, and did so with such remarkable success that physicians no longer consider them to be of high risk. So, why the sudden interest in this group? There is now enough evidence that this population is not as benign as previously thought. They have increased mortality when compared to term infants and are at increased risk for complications including transient tachypnea of newborn (TTN), respiratory distress syndrome (RDS), persistent pulmonary hypertension (PPHN), respiratory failure, temperature instability, jaundice, feeding difficulties and prolonged neonatal intensive care unit (NICU) stay. Evidence is currently emerging that late preterm infants make up a majority of preterm births, take up significant resources, have increased mortality/morbidity, and may even have long-term neurodevelopmental consequences secondary to their late prematurity.
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