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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

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Published on: August 30, 2018

Antimicrobial stewardship: shepherding precious resources.

Robert C Owens¹, Andrew F Shorr, Andrea L Deschambeault

¹Department of Pharmacy, and Clinical Pharmacy Specialist, Infectious Diseases, Division of Infectious Diseases, Maine Medical Center, Portland, ME 04102-3175, USA. owensr@mmc.org

American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists

|June 9, 2009

Summary

This summary is machine-generated.

Implementing antimicrobial stewardship programs (ASPs) improves antimicrobial use and patient safety. Strategies like prior authorization and prospective audit with feedback are key, despite implementation barriers.

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Area of Science:

Infectious Diseases
Health Services Research
Pharmacoeconomics

Background:

Antimicrobial resistance is a growing global health threat.
Widespread and often suboptimal antimicrobial use necessitates improved stewardship.
Antimicrobial stewardship programs (ASPs) offer a structured approach to optimize antimicrobial utilization.

Purpose of the Study:

To discuss various antimicrobial stewardship program (ASP) strategies.
To review evidence supporting the benefits of ASPs.
To identify barriers to ASP implementation and suggest solutions.

Main Methods:

Review of existing literature on ASP strategies, benefits, and barriers.
Analysis of common ASP implementation challenges.
Discussion of potential strategies to overcome identified barriers.

Main Results:

ASPs demonstrably reduce antimicrobial consumption, costs, and resistance.
Key ASP strategies include prior authorization and prospective audit with feedback.
Implementation barriers include funding, leadership support, and personnel shortages.

Conclusions:

ASPs are crucial for judicious antimicrobial use, enhancing patient safety by minimizing medication errors.
Overcoming barriers requires strategic planning, resource allocation, and interdisciplinary collaboration.
Governmental incentives can promote the adoption and resource allocation for ASPs.