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Related Experiment Video

Updated: Jun 22, 2026

Ex Vivo Imaging of Postnatal Cerebellar Granule Cell Migration Using Confocal Macroscopy

Ex Vivo Imaging of Postnatal Cerebellar Granule Cell Migration Using Confocal Macroscopy

Published on: May 12, 2015

Disc1 regulates granule cell migration in the developing hippocampus.

Kate D Meyer¹, Jill A Morris

¹Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Human Molecular Genetics

|June 9, 2009

Summary

This summary is machine-generated.

Investigating the Disrupted-In-Schizophrenia 1 (DISC1) gene

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Last Updated: Jun 22, 2026

Ex Vivo Imaging of Postnatal Cerebellar Granule Cell Migration Using Confocal Macroscopy

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Ex Vivo Culture of Chick Cerebellar Slices and Spatially Targeted Electroporation of Granule Cell Precursors

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Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue

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Published on: October 21, 2021

Area of Science:

Neuroscience
Psychiatric Genetics
Developmental Biology

Background:

Schizophrenia is a debilitating psychiatric disorder linked to neurodevelopmental abnormalities.
The hippocampus shows structural and functional deficits in schizophrenia patients.
The role of the DISC1 gene in hippocampal development is not fully understood.

Purpose of the Study:

To investigate the function of the DISC1 gene in the development of the hippocampus.
To understand how DISC1 influences hippocampal neurodevelopment and its potential link to schizophrenia.

Main Methods:

In utero electroporation of Disc1 shRNA in developing mouse hippocampus.
Analysis of neuronal migration patterns, specifically dentate gyrus granule cells and CA1 pyramidal neurons.

Main Results:

Disc1 knockdown via shRNA hindered the migration of dentate gyrus granule cells.
Disc1 knockdown did not affect the migration of CA1 pyramidal neurons.
This suggests a spatially restricted role for DISC1 in hippocampal neuronal migration.

Conclusions:

DISC1 plays a crucial role in the proper migration of specific hippocampal neurons during development.
Abnormalities in DISC1 function may contribute to schizophrenia pathogenesis by disrupting hippocampal development.
These findings highlight DISC1 as a potential target for understanding and treating schizophrenia.