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Published on: October 10, 2019

Relationship between renal function and serum cardiac troponin T in patients with chronic heart failure

Takayoshi Tsutamoto1, Chiho Kawahara, Masayuki Yamaji

  • 1Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu 520-2192, Japan. tutamoto@belle.shiga-med.ac.jp

European Journal of Heart Failure
|June 9, 2009
PubMed

Insights

Reduced kidney function in chronic heart failure (CHF) patients is linked to higher cardiac troponin T (cTnT) levels. Impaired renal clearance significantly contributes to elevated cTnT in these individuals.

Area of Science:

  • Cardiology
  • Nephrology
  • Biochemistry

Background:

  • Serum cardiac troponin T (cTnT) and renal function are established prognostic indicators in chronic heart failure (CHF).
  • The interplay between renal function and cTnT levels in CHF patients requires further elucidation.

Purpose of the Study:

  • To investigate the relationship between renal function, specifically estimated glomerular filtration rate (eGFR), and serum cTnT concentrations in patients with CHF.
  • To determine if impaired renal function influences cTnT levels and transcardiac gradients.

Main Methods:

  • Serum cTnT concentrations were measured in the aortic root (AO) and coronary sinus (CS) of 258 CHF patients.
  • Patients were stratified into two groups based on eGFR: >or= 60 mL/min/1.73 m(2) (CKD(-)) and < 60 mL/min/1.73 m(2) (CKD (+)).
  • Correlation analyses were performed between eGFR and cTnT levels, and transcardiac gradients were compared between CKD groups.

Main Results:

  • A significant negative correlation was observed between eGFR and serum cTnT concentration (r = -0.365, P = 0.039).
  • No significant difference in the transcardiac gradient of cTnT was found between patients with and without CKD.
  • Serum cTnT levels in the AO were twofold higher in CHF patients with CKD compared to those without CKD (P < 0.05).

Conclusions:

  • Decreased renal clearance plays a significant role in the elevated serum cTnT levels observed in CHF patients with chronic kidney disease (CKD).
  • These findings highlight the importance of considering renal function when interpreting cTnT levels in CHF patients.
Abstract

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