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Updated: Jun 22, 2026
07:40
A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
Published on: May 27, 2021
A critical process controlled by MalT and OmpR is revealed through synthetic lethality
Sylvia A Reimann1, Alan J Wolfe
1Department of Microbiology and Immunology, Loyola University Chicago, 2160 S. First Ave., Maywood, IL 60153, USA.
Journal of Bacteriology
|June 9, 2009
Abstract:
The death of cells harboring defects in two distinct pathways implicates these pathways in the control of an essential process. Here we report that cells lacking OmpR and harboring constitutively active MalT undergo premature death that involves increased expression of the outer membrane porin LamB.
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