Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

CNS Stimulants: Psychedelic Agents

CNS Stimulants: Psychedelic Agents

Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...

Hallucinogens and Psychedelics

Hallucinogens and Psychedelics

Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains delta-9-tetrahydrocannabinol (THC)...

Altered States of Awareness

Altered States of Awareness

Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain that...

Positive Symptoms Schizophrenia: Hallucinations and Delusions

Positive Symptoms Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes loosely...

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The impact of a pandemic as an example of a stressful event, on anxiety and related emotional disorders of NF1 patients compared to healthy children.

Frontiers in psychiatry·2025

Same author

High CCL2 Levels Detected in CSF of Patients with Pediatric Pseudotumor Cerebri Syndrome.

Children (Basel, Switzerland)·2023

Same author

Prospective, Cross-Sectional Study Finds No Common Viruses in Cerebrospinal Fluid of Children with Pseudotumor Cerebri.

Brain sciences·2023

Same author

The Utility of Early Brain MRI for Patients with Neurofibromatosis Type 1 and Optic Pathway Glioma: A Long-Term Follow-Up in a Tertiary Referral Hospital.

Neuropediatrics·2022

Same author

Rolandic Epilepsy - A Silent Enemy. An Instructive Case.

Cureus·2021

Same author

Prognostic Parameters of Acute Transverse Myelitis in Children.

Journal of child neurology·2020

Search research articles

Related Experiment Video

Updated: Jun 22, 2026

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice

Published on: July 9, 2016

Methylphenidate induction of complex visual hallucinations.

Ayelet Halevy¹, Avinoam Shuper

¹Department of Neurology, Schneider Children's Medical Center of Israel, Petach Tikvah, Israel.

Journal of Child Neurology

|June 9, 2009

Summary

This summary is machine-generated.

A 15-year-old boy experienced complex visual hallucinations, including rats, after a low dose of methylphenidate for attention-deficit hyperactivity disorder (ADHD). These hallucinations resolved upon drug discontinuation, suggesting an idiosyncratic reaction to methylphenidate.

More Related Videos

A Novel Approach for Documenting Phosphenes Induced by Transcranial Magnetic Stimulation

A Novel Approach for Documenting Phosphenes Induced by Transcranial Magnetic Stimulation

Published on: April 1, 2010

Combined Infusion and Stimulation with Fast-Scan Cyclic Voltammetry (CIS-FSCV) to Assess Ventral Tegmental Area Receptor Regulation of Phasic Dopamine

Combined Infusion and Stimulation with Fast-Scan Cyclic Voltammetry (CIS-FSCV) to Assess Ventral Tegmental Area Receptor Regulation of Phasic Dopamine

Published on: April 23, 2020

Related Experiment Videos

Last Updated: Jun 22, 2026

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice

Published on: July 9, 2016

A Novel Approach for Documenting Phosphenes Induced by Transcranial Magnetic Stimulation

A Novel Approach for Documenting Phosphenes Induced by Transcranial Magnetic Stimulation

Published on: April 1, 2010

Combined Infusion and Stimulation with Fast-Scan Cyclic Voltammetry (CIS-FSCV) to Assess Ventral Tegmental Area Receptor Regulation of Phasic Dopamine

Combined Infusion and Stimulation with Fast-Scan Cyclic Voltammetry (CIS-FSCV) to Assess Ventral Tegmental Area Receptor Regulation of Phasic Dopamine

Published on: April 23, 2020

Area of Science:

Neuroscience
Psychiatry
Pharmacology

Background:

Attention-deficit hyperactivity disorder (ADHD) is commonly treated with methylphenidate.
Methylphenidate is a central nervous system stimulant.
Visual hallucinations are a rare but reported side effect of methylphenidate.

Observation:

A 15-year-old male with ADHD presented with complex visual hallucinations of rats.
Hallucinations occurred shortly after the first low dose of methylphenidate and resolved upon discontinuation.
The same reaction recurred seven years later with an even lower methylphenidate dose.

Findings:

The case suggests a possible idiosyncratic reaction to methylphenidate, even at very low doses.
The hallucinations were complex and involved vivid sensory experiences.
The pathogenetic mechanism remains unknown, but may involve monoamine transmitter dysfunction.

Implications:

Clinicians should be aware of the potential for methylphenidate-induced hallucinations.
This case highlights the importance of considering drug side effects in patients with ADHD.
Further research into the mechanisms of methylphenidate-induced hallucinations is warranted.