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Related Experiment Video

Updated: Jun 22, 2026

An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei

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Published on: February 17, 2014

How benign is benign tertian malaria?

Archna Sharma¹, Uma Khanduri

¹Department of Haematology, St. Stephen's Hospital, Delhi, India. drarchna_sharma@rediffmail.com

Journal of Vector Borne Diseases

|June 9, 2009

Summary

Plasmodium vivax malaria can cause severe complications like thrombocytopenia, liver and kidney damage, and even death, challenging its benign reputation. This study highlights the incidence of these severe Plasmodium vivax malaria complications.

Area of Science:

Infectious Diseases
Tropical Medicine
Hematology

Background:

Plasmodium vivax malaria is often considered a benign form of malaria.
However, there is a need to understand the spectrum of complications associated with P. vivax infections.

Purpose of the Study:

To determine the incidence of various complications in Plasmodium vivax malaria.
To highlight that P. vivax malaria can present with severe and complicated courses.

Main Methods:

Retrospective review of case records for confirmed malaria cases over one year.
Analysis of complete blood count, liver and kidney function tests, and direct Coomb's test (DCT).
Correlation of rapid diagnostic test results with peripheral blood smear findings.

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Main Results:

Out of 265 malaria cases, 221 were P. vivax.
Complications included thrombocytopenia (213 patients), hepatic dysfunction (60 patients), renal damage (17 patients), positive DCT (2 children), and three maternal deaths due to ARDS.
One patient developed acute renal failure after quinine therapy.

Conclusions:

Plasmodium vivax malaria can lead to severe and complicated outcomes, previously associated mainly with P. falciparum.
Clinicians should be aware of the potential severity of P. vivax malaria.
Further research into P. vivax complications is warranted.