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Updated: Jun 22, 2026
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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
Effects of theaflavins on melanin biosynthesis in mouse b16 melanoma cells
Yuriko Yamaoka1, Kenji Ohguchi, Tomohiro Itoh
1Aichikonan Junior College, Konan, Aichi, Japan.
Bioscience, Biotechnology, and Biochemistry
|June 9, 2009
Abstract:
In this study, we examined the effects of theaflavins, polyphenols in black tea, on alpha melanocyte-stimulating hormone (alphaMSH)-induced melanogenesis in mouse B16 melanoma cells. Among theaflavins, theaflavin-3,3'-digallate (TF-3) exhibited a potent inhibitory effect on melanogenesis. Our results indicate that the inhibitory effect of TF-3 on melanogenesis is due to suppression of tyrosinase protein and mRNA levels.
